The end of an era in mayo clinic proceedings' publishing practices.

Primer on medical genomics. The end of the beginning.

Significance of Perioperative Tests to Diagnose the Infection in Revision Total Shoulder Arthroplasty

Background: The purpose of this study was to evaluate the value of perioperative tests for the diagnosis of infectionin revision shoulder arthroplasty.Methods: A retrospective analysis was performed on 537 shoulder arthroplasties (429 patients) that underwent revisionshoulder arthroplasty at our institution. Periprosthetic tissue cultures were positive in 169/537 surgeries.Results: White-blood ...

Pre-travel Health Care Utilization Among Travelers Who Visit Friends and Relatives

Introduction: Immigrants to the United States who return home to visit friends and relatives (VFRs) have high rates of travel-related infections. The data on VFR utilization of pre-travel health care is inadequate. The objective of this study was to describe the travel patterns and adherence to pre-travel recommendations of VFRs.Methods: This retrospectiv...

Treatment of Glioma in the 21st Century: An Exciting Decade of Postsurgical Treatment Advances in the Molecular Era.

The past decade has brought about major changes in the way we classify and have begun to approach patients with high-grade glioma. As we trend toward personalized medicine, we are now able to utilize the molecular characteristics of each individual's tumor in order to tailor their treatment, particularly if the patient is elderly or has a poor performance status at baseline. We address the stat...

The necessity for clinical reasoning in the era of evidence-based medicine.

Clinical decisions are increasingly driven by evidence-based recommendations of guideline groups, which aim to be based on the highest quality knowledge-randomized clinical trials (RCTs) and meta-analyses. Although RCTs provide the best assessment of the overall value of a therapy, high-quality evidence from RCTs is often incomplete, contradictory, or absent even in areas that have been most ex...